08/19/2016

primobolan cycle

pharmacological properties

It stimulates the incretion primobolan cycle of insulin by beta cells of the pancreas, increases insulinoinkretornoe action of glucose, increases the sensitivity of peripheral tissues to insulin. It stimulates the activity primobolan cycle of intracellular enzymes (including muscle glycogen). It reduces the delay between the time the meal before the incretion of insulin. Incretion restores early peak of insulin (in contrast to other sulfonylureas Рglibenclamide, chlorpropamide, etc., which affect mainly during the second stage incretion.). In addition to the effects on carbohydrate metabolism, improves microcirculation. Reduces adhesion and aggregation of platelets, slows down the development of mural thrombus. It normalizes vascular permeability, prevents the development of mikrotromboza, restores the physiological process of the parietal fibrinolysis. It reduces the sensitivity of vessels to adrenaline. It has anti-atherogenic properties, reduces the concentration of total cholesterol in the blood. Slows the development of diabetic retinopathy in the nonproliferative stage. In diabetic nephropathy in the background of long-term use was a significant reduction in proteinuria. Does not increase body weight, as It has a preferential effect on the early peak of insulin incretion and does not cause hyperinsulinemia. It helps reduce body weight in obese patients, subject to an appropriate diet.

Pharmacokinetics

If ingestion is well absorbed from the gastrointestinal tract. After receiving a single dose of 80mg the maximum plasma concentration is reached after about 4 hours. The connection to plasma proteins primobolan cycle is 94%. It is metabolized in the liver by oxidation, hydroxylation and glucuronidation to form eight metabolites that do not possess hypoglycemic activity, but one of them has a strong influence on the microcirculation. Excreted by the kidneys as metabolites – 70%, in an unmodified form – less than 1%; the feces and the form of metabolites – 12%. The half-life – about 8-11 hours.

Indications

Diabetes mellitus type II (monotherapy and combination therapy with insulin, or the like. Gipoglikemiziruschimi oral preparations).

Contraindications

  • I type I diabetes;
  • diabetic ketoacidosis, diabetic coma and precoma;
  • insuloma;
  • expressed human liver and kidneys;
  • severe microangiopathy;
  • infectious diseases;
  • trauma;
  • major surgery;
  • Hypersensitivity to sulfanilamides and sulfonylureas;
  • pregnancy;
  • lactation (breastfeeding)

Dosing and Administration

Dose is determined individually depending on the age of the patient and clinical manifestations and fasting glycemia 2 hours after meals. The initial daily dose is 80 mg, the average daily dose – 160 mg, the maximum daily dose – 320 mg. Take orally 2 times a day (morning and evening) for 30 minutes before eating.

Side effect

Rarely – allergic reactions (skin rash, urticaria, pruritus); anorexia, nausea, vomiting, diarrhea, feeling of heaviness, or pain in the epigastric region; can usually reversible – thrombocytopenia, leukopenia primobolan cycle or agranulocytosis, anemia. If overdose occur simpomy of hypoglycemia (pale skin, tachycardia, hunger, sweating, trembling, in severe cases – impaired consciousness, coma).

Treatment – if the patient is conscious, glucose or sugar solution was appointed interior, with loss of consciousness in / injected 40% glucose solution or n / a, / m, in / glucagon. After recovery of consciousness in order to avoid a recurrence of hypoglycemia is necessary to give the patient foods rich in carbohydrates.

special instructions

Glidiabom Treatment is carried out in conjunction with a low calorie diet low in carbohydrates. During treatment should regularly monitor the level of fasting plasma glucose and postprandial. Precautions should use the drug in patients with pituitary-adrenal insufficiency, thyroid disease (in violation of its functions), chronic pyelonephritis, alcoholism, as well as in elderly patients. In the case of serious injuries, infectious diseases, surgery is necessary to consider the possibility of insulin preparations. During treatment is not recommended to engage in activities requiring concentration and quick reactions. Need dosage adjustment in the physical and emotional strain, a change of diet. In the case of fasting, drinking alcohol or taking aspirin increases the risk of hypoglycemia. anabolika arten winstrol kaufen anabolika kur

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