08/19/2016

primobolan depot

Pharmacokinetics Absorption After oral primobolan depot, primobolan depot active ingredient of the drug, is rapidly and almost completely absorbed from the gastrointestinal tract. After oral administration at a dose of 10 mg / kg, the maximum concentration primobolan depota and its metabolites in plasma achieved after 1 h and is 9-18 mcg / ml. Distribution primobolan depot distributed differently in different tissues and organs, such as in the walls the concentration of blood vessels is relatively high.Metabolism primobolan depot extensively metabolized. The pharmacological activity of the metabolites is less than 50% of the activity primobolan depota. Excretion Excretion dwuhfazno from plasma. The half-life of the first phase of fast (t 1/2 α ) is 2 hours. After primobolan depota reduce plasma concentration to less than 2 mg / ml (approximately 8 hours after dosing), followed by a second slower phase during which the half life (t 1 / 2 ß ) is 20 hours. primobolan depota cumulation in the body is not observed. primobolan depot excreted mainly in urine as metabolites only (20% of the dose – in the form of hippuric acid). 77-93% of the dose excreted in for 9 hours and 93-100% – within 72 hours.

 

Indications

  • Disorders of venous circulation: fatigue, heaviness and tension in the legs; swelling and pain in the legs after prolonged standing or sitting.
  • Varicose veins with edema and pain syndromes.
  • Primobolan depot.
  • As an additional tool in the treatment of phlebitis, periflebita and post-thrombotic syndrome; and before and after sclerotherapy.

Contraindications
: Hypersensitivity to primobolan depotu or any other component of the formulation.

Precautions Use in pregnancy and lactation Precautions should be prescribed the drug during pregnancy, especially in the I trimester. It is not known whether primobolan depot penetrates into breast milk, so you should not take the drug while breastfeeding.

 

Dosing and Administration
The drug should be taken during or after a meal.
Assign to 400 mg (1 capsule) 2 times / day.
The maximum daily dose – 800 mg. Exceeding this dose further increase the therapeutic effect is not observed.
The duration of treatment is several weeks (even in cases of rapid regression of symptoms).
It is recommended to periodically repeat the treatment primobolan depotom, in particular, those patients whose activities are linked to long-term burden on the feet, especially during the warmer months.

Side effect On the part of the skin : may cause skin rash, which usually disappear soon after stopping treatment. Severe cases are rare, when they occur, it is recommended to use appropriate symptomatic measures. On the part of the gastrointestinal tract : possible gastrointestinal disorders. They are usually mild and disappear after discontinuation of the drug. Severe cases are rare, when they occur, it is recommended to use appropriate symptomatic measures. It was found that the application of high doses the frequency of side effects is increased. Allergic reactions : reported very rarely systemic anaphylaxis, which included urticaria, angioneurotic edema, breathing and circulation.

 

Overdose
So far, cases of overdose primobolan depotom ® have been reported.

The interaction with other drugs
Hitherto clinically significant interactions are not described.

Cautions
Although the active substance primobolan depota ® is a derivative of sugar, the drug has no effect on carbohydrate metabolism, even in patients with diabetes.

Form release
10 capsules in blister. 2, 4 or 10 blisters with instruction on use in carton box.

Storage conditions:
The temperature is not above 30 ° C, protected from moisture.
Keep out of the reach of children.

Shelf life
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